SCHEMBL359355

SCHEMBL359355

CCCOC(=O)C1C(C=O)C1(C)C

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.51
TSHR P16473 1/20 0.39
HCAR2 Q8TDS4 1/20 0.35
PPM1B O75688 1/20 0.35
PTPN1 P18031 1/20 0.35
PPP1CC P36873 1/20 0.35
TDP1 Q9NUW8 3/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
ADRA2A P08913 1/20 0.33
CNR1 P21554 1/20 0.33
ATM Q13315 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1150193 1.00 LMNA (0.51) LMNATSHRHCAR2PPM1BPTPN1
SCHEMBL1150197 1.00 LMNA (0.51) LMNATSHRHCAR2PPM1BPTPN1
SCHEMBL357783 0.90 LMNA (0.49) LMNATSHRHCAR2TDP1MEN1
SCHEMBL1150263 0.90 LMNA (0.49) LMNATSHRHCAR2TDP1MEN1
SCHEMBL1150261 0.90 LMNA (0.49) LMNATSHRHCAR2TDP1MEN1
SCHEMBL1149793 0.88 LMNA (0.47) LMNATSHRHCAR2ATMALDH1A1
SCHEMBL1149791 0.88 LMNA (0.47) LMNATSHRHCAR2ATMALDH1A1
SCHEMBL1149789 0.88 LMNA (0.47) LMNATSHRHCAR2ATMALDH1A1
SCHEMBL1150644 0.87 LMNA (0.46) LMNATSHRHCAR2ALDH1A1
SCHEMBL2126033 0.87 LMNA (0.46) LMNATSHRHCAR2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2412702-B1 METHOD FOR PRODUCING CYCLOPROPANECARBOXYLIC ACID ESTER SUMITOMO CHEMICAL CO (JP) 2014-12-03 EP disclosed
EP-2418197-B1 PROCESS FOR PRODUCING 3-(2-CYANO-1-PROPENYL)-2,2- DIMETHYLCYCLOPROPANECARBOXYLIC ACID OR SALT THEREOF SUMITOMO CHEMICAL CO (JP) 2014-05-07 EP disclosed
EP-1970369-B1 METHOD FOR PRODUCING PURIFIED FORMYLCYCLOPROPANE COMPOUND AND INTERMEDIATE OF SUCH FORMYLCYCLOPROPANE COMPOUND SUMITOMO CHEMICAL CO (JP) 2013-09-25 EP disclosed
US-8461370-B2 Process for producing 3-(2-cyano-1-propenyl)-2,2- dimethylcyclopropanecarboxylic acid or salt thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-06-11 US disclosed
US-8263797-B2 Method for producing cyclopropane carboxylic acid compound and intermediate therefor SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-09-11 US disclosed
US-8168816-B2 Method for producing purified formylcyclopropane compound and intermediate of such formylcyclopropane compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-05-01 US disclosed
EP-1535895-B1 PROCESS FOR PRODUCTION OF FORMYLCYCLOPROPANECARBOXYLIC ESTERS SUMITOMO CHEMICAL CO (JP) 2012-04-25 EP disclosed
EP-2418197-A1 PROCESS FOR PRODUCING 3-(2-CYANO-1-PROPENYL)-2,2- DIMETHYLCYCLOPROPANECARBOXYLIC ACID OR SALT THEREOF Sumitomo Chemical Company, Limited (JP) 2012-02-15 EP disclosed
US-20120029227-A1 METHOD FOR PRODUCING CYCLOPROPANECARBOXYLIC ACID ESTER SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-02 US disclosed
EP-2412702-A1 METHOD FOR PRODUCING CYCLOPROPANECARBOXYLIC ACID ESTER Sumitomo Chemical Company, Limited (JP) 2012-02-01 EP disclosed
EP-2053037-A1 PROCESS FOR PRODUCTION OF TRANS-2,2-DIMETHYL- 3-FORMYLCYCLOPROPANE CARBOXYLIC ACID ESTER Sumitomo Chemical Company, Limited (JP) 2009-04-29 EP disclosed
US-7498459-B2 Method for producing (1-alkenyl)cyclopropane compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-03-03 US disclosed
EP-1970369-A1 METHOD FOR PRODUCING PURIFIED FORMYLCYCLOPROPANE COMPOUND AND INTERMEDIATE OF SUCH FORMYLCYCLOPROPANE COMPOUND Sumitomo Chemical Company, Limited (JP) 2008-09-17 EP disclosed
EP-1463706-B1 PROCESS FOR PRODUCTION OF 3,3-DIMETHYL-2-FORMYLCYCLOPROPANECARBOXYLIC ACID DERIVATIVES SUMITOMO CHEMICAL CO (JP) 2008-02-27 EP disclosed
US-7262320-B2 Process for production of 3,3-dimethyl-2-formylcyclopropanecarboxylic acid derivatives SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-08-28 US disclosed
US-20070197818-A1 Method for producing (1-alkenyl) cyclopropane compound SUMITOMO CHEMICAL COMPANY, LIMITED 2007-08-23 US disclosed
EP-1728781-A1 PROCESS FOR PRODUCTION OF (1-ALKENYL)CYCLOPROPANES Sumitomo Chemical Company, Limited (JP) 2006-12-06 EP disclosed
US-20050240050-A1 Process for production of formylcyclopropanecarboxylic ester SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-10-27 US disclosed
EP-1535895-A1 PROCESS FOR PRODUCTION OF FORMYLCYCLOPROPANECARBOXYLIC ESTERS Sumitomo Chemical Company, Limited (JP) 2005-06-01 EP disclosed
US-20050090685-A1 Process for production of 3,3-dimethyl-2-formylcyclopropanecarboxylic acid derivatives SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-04-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120029227-A1 METHOD FOR PRODUCING CYCLOPROPANECARBOXYLIC ACID ESTER PCCA, COASY, GRHPR LMNA 1488/4885TSHR 1408/4885HCAR2 14/4885
US-20050090685-A1 Process for production of 3,3-dimethyl-2-formylcyclopropanecarboxylic acid derivatives ADSL, CMPK1, MRPL21 LMNA 4209/4885TSHR 3876/4885HCAR2 155/4885
US-20070197818-A1 Method for producing (1-alkenyl) cyclopropane compound ACSL3, ARL1, ACSL1 LMNA 3763/4885TSHR 3751/4885HCAR2 2670/4885
US-20050240050-A1 Process for production of formylcyclopropanecarboxylic ester AHCYL1, HACL2, CBR1 LMNA 4162/4885TSHR 1259/4885HCAR2 61/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.