Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896035 | 0.77 | — | — | |
| SCHEMBL9214047 | 0.65 | TUBB4A (0.38) | NPC1RAB9ASMN1; SMN2DHFR | |
| SCHEMBL4864598 | 0.64 | TUBB4A (0.37) | NPC1RAB9ASMN1; SMN2DHFR | |
| SCHEMBL5478180 | 0.63 | HPGD (0.43) | DHFR | |
| SCHEMBL6627821 | 0.61 | MEN1 (0.39) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3715462 | 0.60 | HPGD (0.45) | POLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5801624 | 0.58 | POLB (0.46) | POLBRAB9ASMN1; SMN2 | |
| SCHEMBL8490366 | 0.57 | DHFR (0.36) | POLBSMN1; SMN2DHFR | |
| SCHEMBL6623681 | 0.55 | RAB9A (0.47) | POLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL638290 | 0.54 | ALDH1A1 (0.61) | POLBNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008036308-A2 | AMINO-SUBSTITUTED HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-03-27 | — | — | WO | disclosed |