Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | IL1RN | P18510 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730491 | 0.93 | SFRP1 (0.50) | SFRP1ALDH1A1KMT2AMEN1EPHX2 | |
| SCHEMBL4733197 | 0.84 | CCR8 (0.43) | KMT2AMEN1 | |
| SCHEMBL4732877 | 0.83 | SFRP1 (0.45) | SFRP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL4733261 | 0.82 | SFRP1 (0.51) | SFRP1ALDH1A1KMT2AMEN1EPHX2 | |
| SCHEMBL4733195 | 0.76 | CCR8 (0.41) | KMT2AMEN1 | |
| SCHEMBL4730139 | 0.75 | SFRP1 (0.45) | SFRP1KMT2AMEN1 | |
| SCHEMBL4734751 | 0.75 | SFRP1 (0.50) | SFRP1ALDH1A1KMT2AMEN1EPHX2 | |
| SCHEMBL4733258 | 0.74 | SFRP1 (0.51) | SFRP1ALDH1A1KMT2AMEN1EPHX2 | |
| SCHEMBL4730240 | 0.73 | CCR8 (0.39) | SFRP1KMT2AMEN1 | |
| SCHEMBL4730986 | 0.73 | SFRP1 (0.46) | SFRP1ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |