Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 12/20 | 0.48 |
| ▸ | WNT3 | P56703 | 5/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730634 | 0.86 | WNT3 (0.37) | SFRP1WNT3HDAC8CCR8BRD4 | |
| SCHEMBL4734140 | 0.84 | SFRP1 (0.45) | SFRP1WNT3 | |
| SCHEMBL4733825 | 0.84 | SFRP1 (0.46) | SFRP1WNT3HDAC8BRD4BRD2 | |
| SCHEMBL4733987 | 0.80 | SFRP1 (0.58) | SFRP1WNT3CCR8BRD4BRD2 | |
| SCHEMBL4734145 | 0.77 | SFRP1 (0.45) | SFRP1WNT3 | |
| SCHEMBL4735405 | 0.74 | HTR1A (0.39) | HDAC8 | |
| SCHEMBL4732698 | 0.74 | GSTO1 (0.38) | HDAC8KDM4EPSEN1PSEN2APH1B | |
| SCHEMBL4733255 | 0.73 | BRD4 (0.44) | SFRP1WNT3CCR8BRD4BRD2 | |
| SCHEMBL4729713 | 0.73 | HTR1A (0.36) | SFRP1WNT3HDAC8BRD4BRD2 | |
| SCHEMBL4731866 | 0.73 | SFRP1 (0.67) | SFRP1WNT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |