Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3 | P56703 | 1/20 | 0.37 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | BRD2 | P25440 | 2/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.34 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732698 | 0.88 | GSTO1 (0.38) | HDAC8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4730889 | 0.86 | SFRP1 (0.48) | WNT3SFRP1HDAC8PSEN1PSEN2 | |
| SCHEMBL4731073 | 0.84 | SFRP1 (0.35) | WNT3SFRP1HDAC8CCR8ALDH1A1 | |
| SCHEMBL4733498 | 0.84 | EPHX2 (0.40) | SFRP1HDAC8CCR8ALDH1A1L3MBTL1 | |
| SCHEMBL4735151 | 0.83 | BRD4 (0.35) | WNT3SFRP1HDAC8PSEN1PSEN2 | |
| SCHEMBL4732377 | 0.81 | WNT3 (0.34) | WNT3SFRP1PSEN1PSEN2APH1B | |
| SCHEMBL4732378 | 0.79 | CCR8 (0.45) | SFRP1BRD4CCR8 | |
| SCHEMBL4732823 | 0.78 | TRPV4 (0.34) | — | |
| SCHEMBL4735405 | 0.76 | HTR1A (0.39) | HDAC8ALDH1A1DPP4KCNH2DPP7 | |
| SCHEMBL4733255 | 0.75 | BRD4 (0.44) | WNT3SFRP1BRD4BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |