Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4728933 | 0.99 | P2RX7 (0.48) | P2RX7RAB9AKDM4EMAPTAGTR1 | |
| SCHEMBL8215561 | 0.83 | HSD11B1 (0.45) | P2RX7RAB9AKDM4EMAPTAGTR1 | |
| SCHEMBL4731571 | 0.77 | CNR1 (0.43) | RAB9AKDM4EMAPTGRM1CYP3A4 | |
| SCHEMBL2518996 | 0.77 | RIPK1 (0.48) | RAB9AMAPTALDH1A1LMNAKMT2A | |
| SCHEMBL13167851 | 0.77 | RIPK1 (0.48) | RAB9AMAPTALDH1A1LMNAKMT2A | |
| SCHEMBL1207556 | 0.77 | RIPK1 (0.48) | RAB9AMAPTALDH1A1LMNAKMT2A | |
| SCHEMBL29730159 | 0.77 | RIPK1 (0.48) | RAB9AMAPTALDH1A1LMNAKMT2A | |
| SCHEMBL3596616 | 0.77 | RIPK1 (0.48) | RAB9AMAPTALDH1A1LMNAKMT2A | |
| SCHEMBL31332780 | 0.77 | RIPK1 (0.48) | RAB9AMAPTALDH1A1LMNAKMT2A | |
| SCHEMBL4727326 | 0.77 | KMT2A (0.41) | P2RX7RAB9AKDM4EMAPTGRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008035049-A1 | ADAMANTANYL-(CYCLOPROPYL)-KETONES AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-03-27 | — | — | WO | disclosed |