Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2707182 | 0.90 | HPGD (0.34) | RXRAHPGDGFERHSD17B10PDK2 | |
| SCHEMBL9980159 | 0.82 | HTR2A (0.32) | HTR2AHTR2CRXRAHPGDGFER | |
| SCHEMBL18462631 | 0.81 | AKR1C3 (0.33) | HPGDPDK2ATML3MBTL1KARS1 | |
| SCHEMBL4730720 | 0.80 | HCAR2 (0.33) | HCAR3HCAR2HTR2ACA12CA1 | |
| SCHEMBL4730918 | 0.75 | GPR3 (0.39) | — | |
| SCHEMBL4734722 | 0.75 | HCAR3 (0.33) | HCAR3HCAR2 | |
| SCHEMBL4730132 | 0.74 | CYP17A1 (0.39) | AGBL2HTR2AHTR2CHPGDGFER | |
| SCHEMBL4732184 | 0.74 | MEN1 (0.39) | AGBL2HPGDGFERHSD17B10CA1 | |
| SCHEMBL4732570 | 0.71 | HSPB1 (0.43) | CA12CA9ALDH1A1ATM | |
| SCHEMBL4730728 | 0.70 | BACE1 (0.35) | HCAR3HCAR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |