Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 7/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.30 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734968 | 0.80 | TRPV4 (0.36) | — | |
| SCHEMBL4730442 | 0.80 | ATM (0.39) | ALDH1A1 | |
| SCHEMBL4732453 | 0.76 | TYMS (0.35) | FFAR4ALDH1A1IDO1 | |
| SCHEMBL4731449 | 0.74 | FFAR4 (0.35) | FFAR4ALDH1A1IDO1 | |
| SCHEMBL4730918 | 0.73 | GPR3 (0.39) | — | |
| SCHEMBL4733825 | 0.71 | SFRP1 (0.46) | — | |
| SCHEMBL4732090 | 0.70 | AGBL2 (0.34) | ALDH1A1HCAR3HCAR2 | |
| SCHEMBL4732570 | 0.70 | HSPB1 (0.43) | BACE1ALDH1A1 | |
| SCHEMBL4731674 | 0.68 | PTGDR2 (0.33) | — | |
| SCHEMBL185520 | 0.67 | ALDH1A1 (0.52) | FFAR4ALDH1A1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |