Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736992 | 0.92 | MEN1 (0.43) | TP53SMN1; SMN2MAPTALDH1A1GAA | |
| SCHEMBL3819010 | 0.71 | RNF4 (0.47) | MEN1KMT2ACNR2CNR1 | |
| SCHEMBL4737523 | 0.68 | ALDH1A1 (0.45) | TP53SMN1; SMN2MAPTALDH1A1GAA | |
| SCHEMBL4734150 | 0.68 | KMT2A (0.48) | ALDH1A1LMNAMEN1KMT2APDK1 | |
| SCHEMBL1246763 | 0.67 | ALDH1A1 (0.50) | TP53SMN1; SMN2MAPTALDH1A1MEN1 | |
| SCHEMBL3822517 | 0.66 | LTB4R2 (0.46) | ALDH1A1MEN1KMT2ACNR2CNR1 | |
| SCHEMBL3819221 | 0.66 | CHRM2 (0.44) | MEN1KMT2ACNR2CNR1 | |
| SCHEMBL8462620 | 0.66 | MAPT (0.45) | MAPTALDH1A1GAALMNAMEN1 | |
| SCHEMBL4735333 | 0.65 | ALDH1A1 (0.48) | TP53ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL4737670 | 0.65 | SMN1; SMN2 (0.46) | TP53SMN1; SMN2MAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |