Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10585501 | 0.79 | CYP1A2 (0.46) | L3MBTL1NISCHADRA2AADRA2BADRA2C | |
| SCHEMBL799296 | 0.79 | NCEH1 (0.55) | TSHRCES2LMNA | |
| SCHEMBL15173067 | 0.78 | GABRA1 (0.42) | L3MBTL1NISCHADRA2AADRA2BADRA2C | |
| SCHEMBL10983999 | 0.77 | LMNA (0.61) | L3MBTL1CYP1A2CYP2C19LMNASLC6A2 | |
| SCHEMBL24813703 | 0.76 | TP53 (0.48) | L3MBTL1TSHRLMNAALDH1A1CA1 | |
| SCHEMBL13158912 | 0.76 | ALDH1A1 (0.39) | L3MBTL1CYP1A2TSHRLMNAALDH1A1 | |
| SCHEMBL22829872 | 0.74 | FABP7 (0.37) | L3MBTL1TSHRCYP2C19LMNAALDH1A1 | |
| SCHEMBL991362 | 0.73 | TSHR (0.50) | L3MBTL1CYP1A2TSHRCYP2C19GABRA1 | |
| SCHEMBL720572 | 0.73 | KDM4E (0.55) | CYP1A2TSHRCYP2C19GABRA1GABRB2 | |
| SCHEMBL7044519 | 0.72 | THRB (0.45) | L3MBTL1ADRA2ATSHRCYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| EP-0302792-B1 | Alkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | SANOFI SA (FR) | 1994-10-26 | — | — | EP | disclosed |
| EP-0302793-B1 | Aralkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | SANOFI ELF (FR) | 1993-12-15 | — | — | EP | disclosed |
| US-5215988-A | Treating angina, hypertension, arrhythmia, cerebral vascular insufficiency | SANOFI (FR) | 1993-06-01 | — | — | US | disclosed |
| US-5147878-A | Hypotensive, antiarrhythmia agents | SANOFI (FR) | 1992-09-15 | — | — | US | disclosed |
| US-5017579-A | Use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure | SANOFI (FR) | 1991-05-21 | — | — | US | disclosed |
| US-4994474-A | Hypotensive agents | SANOFI (FR) | 1991-02-19 | — | — | US | disclosed |
| EP-0302792-A2 | Alkylaminoalkoxyphenyl derivatives, process of preparation and compositions containing the same | SANOFI (FR) | 1989-02-08 | — | — | EP | disclosed |