Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.31 |
| ▸ | TUBB | P07437 | 1/20 | 0.31 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.31 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.31 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.31 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.31 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.31 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.31 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739807 | 0.89 | PTK2 (0.31) | CYP19A1CYP11B1CYP11B2PTK2 | |
| SCHEMBL4738147 | 0.83 | NQO2 (0.42) | CYP19A1CYP11B2NPC1MAPTRAB9A | |
| SCHEMBL4739210 | 0.83 | MIF (0.36) | CYP19A1CYP11B1CYP11B2NPC1MAPT | |
| SCHEMBL4964361 | 0.75 | IDO1 (0.38) | NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4736255 | 0.74 | ALDH1A1 (0.39) | MAPTRAB9ASMN1; SMN2MEN1POLB | |
| SCHEMBL4737338 | 0.73 | KDM4E (0.36) | NPC1RAB9ASMN1; SMN2MEN1GAA | |
| SCHEMBL4735019 | 0.73 | NQO2 (0.38) | CYP19A1CYP11B2MAPT | |
| SCHEMBL4737851 | 0.73 | CYP19A1 (0.32) | CYP19A1CYP11B1CYP11B2NPC1MAPT | |
| SCHEMBL4735017 | 0.72 | — | — | |
| SCHEMBL4735621 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071765-A1 | PHARMACEUTICALLY ACTIVE SPIRO-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2008-06-19 | — | — | WO | disclosed |