Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.54 |
| ▸ | SCD | O00767 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 2/20 | 0.49 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738310 | 0.88 | ALDH1A1 (0.71) | KDM4EALDH1A1POLBMAPTTBK1 | |
| SCHEMBL4737628 | 0.86 | KDM4E (0.64) | KDM4EALDH1A1POLBMAPTTBK1 | |
| SCHEMBL728978 | 0.81 | RAB9A (0.44) | KDM4EALDH1A1LMNAPOLBMAPT | |
| SCHEMBL4737640 | 0.80 | KDM4E (0.63) | KDM4EALDH1A1POLBMAPTTBK1 | |
| SCHEMBL14148402 | 0.79 | KDM4E (0.61) | KDM4EALDH1A1LMNAPOLBMAPT | |
| SCHEMBL4268936 | 0.78 | KDM4E (0.77) | KDM4EALDH1A1POLBMAPTCDC7 | |
| SCHEMBL4737623 | 0.78 | KDM4E (0.60) | KDM4EALDH1A1LMNAMAPTTBK1 | |
| SCHEMBL2303661 | 0.77 | ALDH1A1 (1.00) | KDM4EALDH1A1LMNAPOLBMAPT | |
| SCHEMBL4741747 | 0.77 | MEN1 (0.65) | KDM4EALDH1A1MAPTADORA3ADORA2A | |
| SCHEMBL4740896 | 0.76 | LMNA (0.56) | KDM4EALDH1A1LMNAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |