Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734165 | 0.90 | TAAR1 (0.40) | ALDH1A1NPSR1HTTPOLBSMN1; SMN2 | |
| SCHEMBL4732636 | 0.87 | ACHE (0.44) | ALDH1A1HTTSMN1; SMN2MAPTKDM4E | |
| SCHEMBL4737048 | 0.81 | TBXAS1 (0.39) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4732880 | 0.80 | KMT2A (0.37) | ALDH1A1NPSR1L3MBTL1MEN1KMT2A | |
| SCHEMBL4735469 | 0.78 | ACHE (0.41) | ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL4731530 | 0.76 | BRD4 (0.37) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL4732619 | 0.72 | TAAR1 (0.43) | ALDH1A1NPSR1HTTPOLBSMN1; SMN2 | |
| SCHEMBL4734516 | 0.71 | DRD2 (0.32) | ALDH1A1NPSR1SFRP1MEN1KMT2A | |
| SCHEMBL4734512 | 0.70 | BRD4 (0.46) | ALDH1A1HTTSFRP1L3MBTL1MAPT | |
| SCHEMBL4639266 | 0.69 | SFRP1 (0.59) | ALDH1A1NPSR1HTTPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |