Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GPR3 | P46089 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732884 | 0.87 | EGFR (0.39) | KMT2AMEN1ALDH1A1EGFRERBB2 | |
| SCHEMBL4736394 | 0.85 | TGM2 (0.34) | CA12CA1CA2CA4CA7 | |
| SCHEMBL4737700 | 0.80 | ALDH1A1 (0.40) | KMT2AMEN1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL4731530 | 0.78 | BRD4 (0.37) | KMT2AMEN1ALDH1A1NPC1MAPT | |
| SCHEMBL4732636 | 0.76 | ACHE (0.44) | ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL4736397 | 0.76 | TGM2 (0.36) | EGFRERBB2IGF1RPDGFRBNOX4 | |
| SCHEMBL4734512 | 0.72 | BRD4 (0.46) | ALDH1A1NPC1MAPTL3MBTL1 | |
| SCHEMBL4734516 | 0.71 | DRD2 (0.32) | KMT2AMEN1ALDH1A1NPC1MAPT | |
| SCHEMBL4734165 | 0.70 | TAAR1 (0.40) | KMT2AMEN1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL5710957 | 0.69 | KMT2A (0.67) | KMT2AMEN1ALDH1A1MAOACHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |