Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737984 | 0.93 | ALDH1A1 (0.53) | LMNAALDH1A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL4739792 | 0.91 | LMNA (0.49) | LMNAALDH1A1KDM4ETSHRCYP3A4 | |
| SCHEMBL4734088 | 0.91 | LMNA (0.53) | LMNAALDH1A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL4735586 | 0.90 | LMNA (0.53) | LMNAALDH1A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL4735444 | 0.90 | LMNA (0.52) | LMNAALDH1A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL4735594 | 0.89 | OPRM1 (0.48) | LMNAALDH1A1KDM4ETSHRDRD4 | |
| SCHEMBL4738686 | 0.88 | OPRM1 (0.55) | LMNAALDH1A1KDM4ETSHRDRD4 | |
| SCHEMBL4740309 | 0.87 | LMNA (0.46) | LMNAALDH1A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL4737347 | 0.85 | DRD4 (0.43) | LMNAALDH1A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL4736215 | 0.85 | LMNA (0.48) | LMNAALDH1A1KDM4ETSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |