Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735444 | 0.89 | LMNA (0.52) | LMNAKDM4ESMN1; SMN2OPRM1MEN1 | |
| SCHEMBL4734088 | 0.88 | LMNA (0.53) | LMNAKDM4ESMN1; SMN2OPRM1MEN1 | |
| SCHEMBL4737945 | 0.87 | OPRM1 (0.44) | LMNAKDM4EOPRM1TP53ALDH1A1 | |
| SCHEMBL4735586 | 0.86 | LMNA (0.53) | LMNAKDM4ESMN1; SMN2OPRM1MEN1 | |
| SCHEMBL4736215 | 0.85 | LMNA (0.48) | LMNAKDM4ESMN1; SMN2OPRM1MEN1 | |
| SCHEMBL4737984 | 0.85 | ALDH1A1 (0.53) | LMNAKDM4ESMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL4739792 | 0.85 | LMNA (0.49) | LMNAKDM4EOPRM1MEN1KMT2A | |
| SCHEMBL4738710 | 0.85 | LMNA (0.49) | LMNAKDM4ESMN1; SMN2OPRM1MEN1 | |
| SCHEMBL4733572 | 0.84 | TSHR (0.45) | KDM4EHRH3OPRM1CXCR3TP53 | |
| SCHEMBL4735594 | 0.83 | OPRM1 (0.48) | LMNAKDM4EOPRM1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |