Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.67 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.67 |
| ▸ | CES1 | P23141 | 9/20 | 0.50 |
| ▸ | TGM2 | P21980 | 2/20 | 0.50 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 2/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29870149 | 1.00 | ALDH1A1 (0.67) | ALDH1A1ALDH2ALDH3A1CES1TGM2 | |
| SCHEMBL21197529 | 0.83 | ALDH1A1 (0.47) | ALDH1A1ALDH2ALDH3A1CES1TGM2 | |
| SCHEMBL11921145 | 0.83 | ALDH1A1 (0.47) | ALDH1A1ALDH2ALDH3A1CES1TGM2 | |
| SCHEMBL2372881 | 0.80 | CES1 (0.68) | ALDH1A1ALDH2ALDH3A1CES1TGM2 | |
| SCHEMBL31049292 | 0.80 | TGM2 (0.67) | ALDH1A1ALDH2ALDH3A1CES1TGM2 | |
| SCHEMBL24619205 | 0.80 | TGM2 (0.67) | ALDH1A1ALDH2ALDH3A1CES1TGM2 | |
| SCHEMBL3737904 | 0.80 | CES1 (0.62) | ALDH1A1ALDH2ALDH3A1CES1TGM2 | |
| SCHEMBL12069195 | 0.80 | TGM2 (0.67) | ALDH1A1ALDH2ALDH3A1CES1TGM2 | |
| SCHEMBL30762569 | 0.80 | CES1 (0.68) | ALDH1A1ALDH2ALDH3A1CES1TGM2 | |
| SCHEMBL30762476 | 0.80 | ALDH1A1 (1.00) | ALDH1A1ALDH2ALDH3A1CES1TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117486780-A | 1-benzyl isatin derivative and preparation method and application thereof | 武汉大学人民医院（湖北省人民医院） | 2024-02-02 | — | — | CN | claimed |
| US-12616678-B2 | Methods to of aldehyde dehydrogenases for treatment of cancer | THE PENN STATE RESEARCH FOUNDATION (PA) | 2026-05-05 | — | — | US | disclosed |
| US-20250387367-A1 | METHODS AND COMPOSITIONS RELATING TO INHIBITION OF ALDEHYDE DEHYDROGENASES FOR TREATMENT OF CANCER | PENN STATE RES FOUND (US) | 2025-12-25 | — | — | US | disclosed |
| CN-118125961-A | 1- (4-Trifluoromethyl-benzyl) -isatin derivative and preparation method and application thereof | 武汉大学人民医院（湖北省人民医院） | 2024-06-04 | — | — | CN | disclosed |
| CN-117658981-A | Isatin derivative, pharmaceutically acceptable salt, pharmaceutical composition and application | 武汉大学人民医院（湖北省人民医院） | 2024-03-08 | — | — | CN | disclosed |
| CN-117486780-A | 1-benzyl isatin derivative and preparation method and application thereof | 武汉大学人民医院（湖北省人民医院） | 2024-02-02 | — | — | CN | disclosed |
| US-20230301965-A1 | METHODS AND COMPOSITIONS RELATING TO INHIBITION OF ALDEHYDE DEHYDROGENASES FOR TREATMENT OF CANCER | THE PENN STATE RESEARCH FOUNDATION | 2023-09-28 | — | — | US | disclosed |
| US-20230301965-A1 | METHODS AND COMPOSITIONS RELATING TO INHIBITION OF ALDEHYDE DEHYDROGENASES FOR TREATMENT OF CANCER | THE PENN STATE RESEARCH FOUNDATION | 2023-09-28 | — | — | US | disclosed |
| US-20220267329-A1 | Dihydro-Spiro[Indoline-3:1'-Isoquinolin]-2-Ones and Their Analogues and Derivatives and Methods of Treating Cancer and Other Diseases | THE UNIV OF BUEA (CM) | 2022-08-25 | — | — | US | disclosed |
| US-20220175723-A1 | METHODS AND COMPOSITIONS RELATING TO INHIBITION OF ALDEHYDE DEHYDROGENASES FOR TREATMENT OF CANCER | THE PENN STATE RESEARCH FOUNDATION | 2022-06-09 | — | — | US | disclosed |
| CN-102653521-B | Piperazine thiocarbohydrazide derivate of indole-2-ketone and preparation method and application of piperazine thiocarbohydrazide derivate | UNIV CAPITAL NORMAL | 2014-08-06 | — | — | CN | disclosed |
| CN-102464603-B | Isatin derivative and application thereof in preparation of medicines for resisting super-drug-resistance bacteria | UNIV NANKAI | 2013-08-14 | — | — | CN | disclosed |
| CN-102464603-A | Isatin derivative and application thereof in preparation of medicines for resisting super-drug-resistance bacteria | UNIV NANKAI | 2012-05-23 | — | — | CN | disclosed |
| WO-2008074078-A1 | SELECTIVELY DELIVERABLE ISATIN-BASED CYTOTOXIC AGENTS | UNIVERSITY OF WOLLONGONG (AU) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008074078-A1 | SELECTIVELY DELIVERABLE ISATIN-BASED CYTOTOXIC AGENTS | UNIVERSITY OF WOLLONGONG (AU) | 2008-06-26 | — | — | WO | disclosed |
| US-20030121113-A1 | Oxobenzofuranylide-dihydroindolone | NESVADBA PETER (CH) | 2003-07-03 | — | — | US | disclosed |
| US-6503937-B1 | Coloring agents for high molecular weight materials such as polymers | CIBA SPECIALTY CHEMICALS CORPORATION | 2003-01-07 | — | — | US | disclosed |
| US-20020028936-A1 | 1,3-disubstituted indolin-2-ones for neoplasia | OSI PHARMACEUTICALS, INC. | 2002-03-07 | — | — | US | disclosed |
| US-4436810-A | Color-photographic recording material containing non-diffusing electron donor precursor compounds | AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) | 1984-03-13 | — | — | US | disclosed |
| US-4185009-A | Branched, high-molecular weight thermoplastic polycarbonates | BAYER AKTIENGESELLSCHAFT (DE) | 1980-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250387367-A1 | METHODS AND COMPOSITIONS RELATING TO INHIBITION OF ALDEHYDE DEHYDROGENASES FOR TREATMENT OF CANCER | ALDH3A1, ALDH2, ADH1C | ALDH1A1 4/4885ALDH2 2/4885ALDH3A1 1/4885 |
| US-20220175723-A1 | METHODS AND COMPOSITIONS RELATING TO INHIBITION OF ALDEHYDE DEHYDROGENASES FOR TREATMENT OF CANCER | DPYD, ALDH2, DLD | ALDH1A1 6/4885ALDH2 2/4885ALDH3A1 4/4885 |
| US-20030121113-A1 | Oxobenzofuranylide-dihydroindolone | CYP1B1, CYP1A1, ECI1 | ALDH1A1 225/4885ALDH2 808/4885ALDH3A1 538/4885 |
| US-12616678-B2 | Methods to of aldehyde dehydrogenases for treatment of cancer | ALDH1A1, ALDH3A1, ADH1C | ALDH1A1 1/4885ALDH2 4/4885ALDH3A1 2/4885 |
| US-20020028936-A1 | 1,3-disubstituted indolin-2-ones for neoplasia | TP53, MYC, VHL | ALDH1A1 215/4885ALDH2 1569/4885ALDH3A1 561/4885 |
| US-20220267329-A1 | Dihydro-Spiro[Indoline-3:1'-Isoquinolin]-2-Ones and Their Analogues and Derivatives and Methods of Treating Cancer and Other Diseases | S1PR3, S1PR1, S1PR2 | ALDH1A1 1086/4885ALDH2 1083/4885ALDH3A1 796/4885 |
| US-20230301965-A1 | METHODS AND COMPOSITIONS RELATING TO INHIBITION OF ALDEHYDE DEHYDROGENASES FOR TREATMENT OF CANCER | DPYD, ALDH2, DLD | ALDH1A1 6/4885ALDH2 2/4885ALDH3A1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.