Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474431 | 0.92 | TRPV1 (0.41) | GAAALDH1A1LMNATRPV1NR3C2 | |
| SCHEMBL473958 | 0.83 | ALDH1A1 (0.37) | ALDH1A1LMNA | |
| SCHEMBL12163967 | 0.75 | GAA (0.38) | GAANR3C2NR3C1KMT2APGR | |
| SCHEMBL474394 | 0.75 | POLB (0.36) | ALDH1A1 | |
| SCHEMBL474603 | 0.75 | GAA (0.38) | GAANR3C2NR3C1KMT2APGR | |
| SCHEMBL474633 | 0.75 | ALDH1A1 (0.41) | GAAALDH1A1PGR | |
| SCHEMBL473904 | 0.74 | ALDH1A1 (0.46) | ALDH1A1MAPK1MAPTKMT2A | |
| SCHEMBL474455 | 0.74 | ALDH1A1 (0.34) | ALDH1A1LMNA | |
| SCHEMBL474051 | 0.74 | ALDH1A1 (0.39) | ALDH1A1MAPTKMT2A | |
| SCHEMBL15520761 | 0.72 | NR3C2 (0.37) | ALDH1A1NR3C2MAPTNR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411365-A1 | 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2012-02-01 | — | — | EP | disclosed |