Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787140 | 0.87 | POLB (0.51) | GAACYP2C19POLBALDH1A1USP2 | |
| SCHEMBL4740909 | 0.85 | CYP2C19 (0.46) | GAACYP2C19ALDH1A1USP2HSD17B10 | |
| SCHEMBL4741026 | 0.85 | ALDH1A1 (0.52) | GAACYP2C19POLBALDH1A1USP2 | |
| SCHEMBL4736655 | 0.83 | HSD17B10 (0.47) | GAAHTTCYP2C19ALDH1A1USP2 | |
| SCHEMBL4740423 | 0.82 | SIRT2 (0.48) | GAAHTTPOLBMAPTALDH1A1 | |
| SCHEMBL4795192 | 0.81 | CYP3A4 (0.55) | GAAHTTCYP2C19POLBMAPT | |
| SCHEMBL4740406 | 0.79 | ALDH1A1 (0.44) | GAAHTTRAB9APOLBALDH1A1 | |
| SCHEMBL4740078 | 0.78 | GAA (0.50) | GAAHTTCYP2C19RAB9AMAPT | |
| SCHEMBL4736817 | 0.77 | HTT (0.46) | HTTPOLBMAPTALDH1A1LMNA | |
| SCHEMBL4807472 | 0.76 | CYP3A4 (0.50) | GAAHTTCYP2C19POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | disclosed |