Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPN | P05981 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30960381 | 1.00 | ALDH1A1 (0.40) | ALDH1A1MAPTALOX15HSD17B10TDP1 | |
| 4,8-Dihydroxy-1-Tetralone SCHEMBL27988260 | 0.73 | POLL (0.62) | ALDH1A1MAPTALOX15HSD17B10TDP1 | |
| 4,8-Dihydroxy-1-Tetralone SCHEMBL6281138 | 0.73 | POLL (0.62) | ALDH1A1MAPTALOX15HSD17B10TDP1 | |
| 4,8-Dihydroxy-1-Tetralone SCHEMBL30966482 | 0.73 | POLL (0.62) | ALDH1A1MAPTALOX15HSD17B10TDP1 | |
| SCHEMBL4364362 | 0.70 | MAOA (0.42) | MEN1KMT2AMAOAMAOBHTR2A | |
| SCHEMBL10490934 | 0.68 | ALDH1A1 (0.55) | ALDH1A1MAPTALOX15HSD17B10TDP1 | |
| SCHEMBL31142200 | 0.67 | ESR1 (0.41) | CYP3A4PTGS1MAOAMAOBMAPK1 | |
| SCHEMBL14113261 | 0.66 | MAOA (0.56) | ALDH1A1MAPTALOX15HSD17B10TDP1 | |
| SCHEMBL27721949 | 0.66 | STAT3 (0.43) | ALDH1A1MAPTALOX15HSD17B10TDP1 | |
| SCHEMBL23707669 | 0.65 | CES2 (0.50) | ALDH1A1MAPTALOX15HSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008100977-A2 | CARBAMATES THERAPEUTIC RELEASE AGENTS AS AMIDASE INHIBITORS | N.V. ORGANON (NL) | 2008-08-21 | — | — | WO | disclosed |