SCHEMBL4743205

SCHEMBL4743205

O=C(O)NC1(F)C=CC=CC1c1ccc(F)cc1

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 1/20 0.33
HSD11B1 P28845 1/20 0.31
EPHX1 P07099 1/20 0.31
MEN1 O00255 1/20 0.30
LMNA P02545 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20573254 0.83 HDAC4 (0.33) HSD11B1LMNAKMT2A
SCHEMBL3475974 0.73 ALDH1A1 (0.34)
SCHEMBL6231235 0.73 MAOB (0.32)
SCHEMBL4539515 0.72 LMNA (0.43) LMNA
SCHEMBL9851147 0.67 NPC1 (0.37) HSD11B1EPHX1MEN1LMNAKMT2A
SCHEMBL16599817 0.64 HTR2A (0.33) LMNA
SCHEMBL17984328 0.63 KDM1A (0.41) PTGS2
SCHEMBL28797358 0.62 RXRA (0.36) MEN1KMT2A
SCHEMBL9358499 0.62 HSD11B1 (0.40) PTGS2HSD11B1MEN1KMT2A
SCHEMBL5497731 0.59 HSD11B1 (0.32) HSD11B1MEN1LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3029026-B1 NOVEL BIPHENYL DERIVATIVE AND METHOD FOR PREPARING SAME DONG A ST CO LTD (KR) 2018-12-05 EP claimed
EP-1904446-A2 AZABICYCLO DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS Ranbaxy Laboratories Limited (IN) 2008-04-02 EP disclosed
WO-2007007282-A2 AZABICYCLO DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS RANBAXY LABORATORIES LIMITED (IN) 2007-01-18 WO disclosed