Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 6/20 | 0.49 |
| ▸ | GNAO1 | P09471 | 6/20 | 0.49 |
| ▸ | GNAI1 | P63096 | 6/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.41 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743328 | 0.87 | KDM1A (0.37) | GNAI3GNAO1GNAI1L3MBTL3TSHR | |
| SCHEMBL144841 | 0.81 | GNAI3 (0.50) | GNAI3GNAO1GNAI1L3MBTL3L3MBTL1 | |
| SCHEMBL13461191 | 0.79 | GNAI3 (0.45) | GNAI3GNAO1GNAI1L3MBTL3L3MBTL1 | |
| SCHEMBL13801425 | 0.79 | GNAI3 (0.53) | GNAI3GNAO1GNAI1L3MBTL3L3MBTL1 | |
| SCHEMBL28247533 | 0.78 | MBTD1 (0.45) | L3MBTL3ITGB3ITGA2BTSHRMBTD1 | |
| SCHEMBL242268 | 0.77 | — | — | |
| SCHEMBL4437908 | 0.77 | GNAI3 (0.49) | GNAI3GNAO1GNAI1L3MBTL3L3MBTL1 | |
| SCHEMBL1400926 | 0.76 | L3MBTL3 (0.45) | L3MBTL3L3MBTL1CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL13772844 | 0.76 | GNAI3 (0.58) | GNAI3GNAO1GNAI1L3MBTL3L3MBTL1 | |
| Water SCHEMBL15152290 | 0.75 | CA2 (0.52) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912972-A1 | SUBSTITUTED IMIDAZOLE COMPOUNDS AS KSP INHIBITORS | Novartis AG (CH) | 2008-04-23 | — | — | EP | claimed |
| WO-2007021794-A1 | SUBSTITUTED IMIDAZOLE COMPOUNDS AS KSP INHIBITORS | NOVARTIS AG (CH) | 2007-02-22 | — | — | WO | claimed |