Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARBP2 | Q15633 | 5/20 | 0.64 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PDCD4 | Q53EL6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4742423 | 0.89 | TARBP2 (0.62) | TARBP2GABRA2GABRB2MAPTTRPM8 | |
| SCHEMBL18003815 | 0.88 | TARBP2 (0.78) | TARBP2GABRA2GABRB2ALOX5MAPT | |
| SCHEMBL4738984 | 0.86 | GABRA2 (0.51) | TARBP2GABRA2GABRB2MAPTTRPM8 | |
| SCHEMBL1968359 | 0.86 | TARBP2 (0.59) | TARBP2GABRA2GABRB2MAPTTRPM8 | |
| SCHEMBL13056699 | 0.85 | TARBP2 (0.64) | TARBP2GABRA2GABRB2MAPTHSD17B10 | |
| SCHEMBL4786522 | 0.84 | ALOX5 (0.55) | TARBP2GABRA2GABRB2ALOX5MAPT | |
| SCHEMBL4742519 | 0.83 | MAPT (0.52) | TARBP2MAPTKDM4EPDCD4 | |
| SCHEMBL18003564 | 0.82 | TARBP2 (0.70) | TARBP2GABRA2GABRB2ALOX5MAPT | |
| SCHEMBL15507362 | 0.81 | RAB9A (0.47) | TARBP2MAPTHSD17B10KDM4EALDH1A1 | |
| SCHEMBL1167143 | 0.81 | NPC1 (0.45) | TARBP2GABRA2GABRB2ALOX5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087611-A2 | PYRROLIDINE- AND PIPERIDINE- BIS-AMIDE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-07-24 | — | — | WO | disclosed |