Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.55 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738316 | 0.87 | TARBP2 (0.48) | L3MBTL1TARBP2ALDH1A1ELANEJAK2 | |
| SCHEMBL1340374 | 0.85 | TRPM8 (0.53) | TRPM8L3MBTL1TARBP2ALDH1A1ELANE | |
| SCHEMBL4743899 | 0.84 | TARBP2 (0.64) | ALOX5TRPM8GABRA2GABRB2TARBP2 | |
| SCHEMBL1968359 | 0.84 | TARBP2 (0.59) | TRPM8GABRA2GABRB2L3MBTL1TARBP2 | |
| SCHEMBL1969979 | 0.84 | TARBP2 (0.50) | TARBP2ALDH1A1ELANEKDM4EHPGD | |
| SCHEMBL9750650 | 0.83 | ALOX5 (0.48) | ALOX5TRPM8GABRA2GABRB2L3MBTL1 | |
| SCHEMBL1166739 | 0.83 | PIN1 (0.56) | L3MBTL1ALDH1A1KMT2AFPR2 | |
| SCHEMBL1965950 | 0.82 | MEN1 (0.55) | TARBP2ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL27900801 | 0.80 | PIN1 (0.40) | ALOX5TRPM8GABRA2GABRB2L3MBTL1 | |
| SCHEMBL1545025 | 0.80 | L3MBTL1 (0.53) | ALOX5TRPM8GABRA2GABRB2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087611-A2 | PYRROLIDINE- AND PIPERIDINE- BIS-AMIDE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-07-24 | — | — | WO | disclosed |