Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARBP2 | Q15633 | 6/20 | 0.62 |
| ▸ | PDCD4 | Q53EL6 | 1/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743899 | 0.89 | TARBP2 (0.64) | TARBP2PDCD4TRPM8GABRA2GABRB2 | |
| SCHEMBL4738984 | 0.89 | GABRA2 (0.51) | TARBP2PDCD4TRPM8GABRA2GABRB2 | |
| SCHEMBL1968359 | 0.88 | TARBP2 (0.59) | TARBP2TRPM8GABRA2GABRB2CYP1A2 | |
| SCHEMBL13056699 | 0.87 | TARBP2 (0.64) | TARBP2PDCD4GABRA2GABRB2ALDH1A1 | |
| SCHEMBL4742519 | 0.85 | MAPT (0.52) | TARBP2PDCD4KMT2AKDM4EMAPT | |
| SCHEMBL4738316 | 0.83 | TARBP2 (0.48) | TARBP2CYP1A2ALDH1A1KMT2AKDM4E | |
| SCHEMBL15507362 | 0.83 | RAB9A (0.47) | TARBP2PDCD4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1166974 | 0.80 | IKBKB (0.44) | TARBP2ALDH1A1KMT2AKDM4EHPGD | |
| SCHEMBL1340374 | 0.79 | TRPM8 (0.53) | TARBP2TRPM8CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4786522 | 0.79 | ALOX5 (0.55) | TARBP2TRPM8GABRA2GABRB2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087611-A2 | PYRROLIDINE- AND PIPERIDINE- BIS-AMIDE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-07-24 | — | — | WO | disclosed |