Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746087 | 0.74 | KMT2A (0.53) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL5562243 | 0.73 | L3MBTL1 (0.67) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL3867855 | 0.71 | CA1 (0.59) | ALDH1A1CA1CA2MMP1MMP2 | |
| SCHEMBL19808496 | 0.71 | ALDH1A1 (0.53) | ALDH1A1CA2HTTKMT2AHSD17B10 | |
| SCHEMBL19808245 | 0.70 | P2RX7 (0.53) | ALDH1A1CA2LMNASMN1; SMN2KMT2A | |
| SCHEMBL8353239 | 0.70 | CA1 (0.57) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL5963342 | 0.70 | FABP4 (0.76) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL3687291 | 0.68 | L3MBTL1 (0.61) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL3325063 | 0.68 | HSD11B1 (0.60) | P2RX7 | |
| SCHEMBL17101162 | 0.67 | L3MBTL1 (0.59) | CA1CA2MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112251-A1 | CYCLOPROPYL-CONTAINING POLYAMINE ANALOGS AS DISEASE THERAPIES | PROGEN PHARMACEUTICALS, INC. (US) | 2008-09-18 | — | — | WO | disclosed |