Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | USP5 | P45974 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746067 | 0.91 | KMT2A (0.46) | ACLYTHRBKMT2AMEN1CYP2D6 | |
| SCHEMBL4788418 | 0.89 | THRB (0.47) | THRBKMT2AMEN1CYP2D6CYP1A2 | |
| SCHEMBL8153861 | 0.89 | ACLY (0.45) | ACLYTHRBKMT2AMEN1CYP2D6 | |
| SCHEMBL4746885 | 0.88 | KMT2A (0.44) | ACLYTHRBKMT2AMEN1CYP2D6 | |
| SCHEMBL4746866 | 0.87 | HTT (0.48) | THRBKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL4746863 | 0.86 | MAPT (0.45) | ACLYKMT2AUSP5TP53MAPT | |
| SCHEMBL8161152 | 0.85 | TP53 (0.45) | ACLYTHRBKMT2AMEN1CYP2D6 | |
| SCHEMBL4786482 | 0.83 | TSHR (0.42) | THRBKMT2AMEN1CYP2D6CYP1A2 | |
| SCHEMBL4745402 | 0.82 | KMT2A (0.44) | THRBKMT2AMEN1CYP2D6CYP3A4 | |
| SCHEMBL4785661 | 0.81 | KMT2A (0.50) | THRBKMT2AMEN1CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | claimed |
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | disclosed |