Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | USP5 | P45974 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | USP3 | Q9Y6I4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4742206 | 0.90 | ALDH1A1 (0.43) | MAPTTP53ALDH1A1GAAPOLB | |
| SCHEMBL4746102 | 0.86 | ACLY (0.44) | MAPTTP53ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL4786708 | 0.86 | MAPT (0.46) | MAPTTP53ALDH1A1GAAPOLB | |
| SCHEMBL8161152 | 0.83 | TP53 (0.45) | MAPTTP53ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL4746166 | 0.80 | TSHR (0.43) | MAPTALDH1A1GAAPOLBSMN1; SMN2 | |
| SCHEMBL4746814 | 0.80 | TP53 (0.43) | MAPTTP53ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL4788634 | 0.79 | SMN1; SMN2 (0.48) | MAPTALDH1A1GAAPOLBSMN1; SMN2 | |
| SCHEMBL4746067 | 0.78 | KMT2A (0.46) | MAPTTP53ALDH1A1POLBACLY | |
| SCHEMBL4745401 | 0.78 | TSHR (0.47) | MAPTTP53ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL8160491 | 0.77 | ACLY (0.50) | MAPTTP53ALDH1A1SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | claimed |