Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1957955 | 0.87 | HTR7 (0.46) | ALDH1A1CA12CA1CA2CA14 | |
| SCHEMBL5205282 | 0.85 | CA12 (0.49) | MEN1KMT2AKDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL9287986 | 0.83 | P2RX7 (0.45) | MEN1KMT2AHTR2AHTR2CKDM4E | |
| SCHEMBL29957820 | 0.79 | ALDH1A1 (0.54) | KDM4EL3MBTL1ALDH1A1CHRM2CHRM1 | |
| SCHEMBL249539 | 0.79 | ALDH1A1 (0.54) | KDM4EL3MBTL1ALDH1A1CHRM2CHRM1 | |
| SCHEMBL29143297 | 0.79 | HTR2A (0.45) | MEN1KMT2AHTR2AHTR2CKDM4E | |
| SCHEMBL16674078 | 0.77 | CA1 (0.55) | KDM4EALDH1A1CA12CA1CA2 | |
| SCHEMBL196440 | 0.77 | MGAM (0.55) | KDM4EALDH1A1CA12CA1CA2 | |
| SCHEMBL6767194 | 0.76 | HTR7 (0.50) | HTR2AHTR2CKDM4EHTR1A | |
| SCHEMBL6536022 | 0.76 | ERN1 (0.54) | KDM4EALDH1A1CA1CA2NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123821-A1 | 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-10-16 | — | — | WO | disclosed |