Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4748799 | 0.84 | MTNR1A (0.35) | ALDH1A1RENKDM4EHPGDNPC1 | |
| SCHEMBL4746196 | 0.79 | REN (0.36) | LMNARENKDM4EHPGDPOLB | |
| SCHEMBL4748944 | 0.78 | KAT6A (0.41) | REN | |
| SCHEMBL2852276 | 0.72 | REN (0.40) | ALDH1A1RENKDM4EMAPTKMT2A | |
| SCHEMBL2852273 | 0.72 | REN (0.40) | ALDH1A1RENKDM4EMAPTKMT2A | |
| SCHEMBL5592088 | 0.68 | REN (0.41) | RENMAPTNPC1RAB9A | |
| SCHEMBL19437299 | 0.66 | PDK1 (0.45) | ALDH1A1LMNAPOLBCYP3A4CYP2C19 | |
| SCHEMBL22836516 | 0.65 | PDK1 (0.51) | ALDH1A1LMNAPOLBRAB9A | |
| SCHEMBL22836681 | 0.65 | PDK1 (0.51) | ALDH1A1LMNAPOLBRAB9A | |
| SCHEMBL2847191 | 0.65 | REN (0.39) | LMNARENNPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124582-A1 | RENIN INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-16 | — | — | WO | disclosed |