Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 2/20 | 0.41 |
| ▸ | KAT5 | Q92993 | 2/20 | 0.41 |
| ▸ | KAT7 | O95251 | 2/20 | 0.39 |
| ▸ | REN | P00797 | 2/20 | 0.37 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.37 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746196 | 0.88 | REN (0.36) | REN | |
| SCHEMBL4748799 | 0.79 | MTNR1A (0.35) | REN | |
| SCHEMBL4746988 | 0.78 | ALDH1A1 (0.34) | REN | |
| SCHEMBL3557758 | 0.74 | REN (0.43) | KAT6AKAT5KAT7RENGPR119 | |
| SCHEMBL3557762 | 0.74 | REN (0.43) | KAT6AKAT5KAT7RENGPR119 | |
| SCHEMBL3557756 | 0.74 | REN (0.43) | KAT6AKAT5KAT7RENGPR119 | |
| SCHEMBL3877929 | 0.73 | REN (0.40) | KAT6AKAT5KAT7RENEPHA2 | |
| SCHEMBL3943237 | 0.71 | GPR119 (0.41) | KAT6AKAT5KAT7RENKAT8 | |
| SCHEMBL3943233 | 0.71 | GPR119 (0.41) | KAT6AKAT5KAT7RENKAT8 | |
| SCHEMBL3881718 | 0.71 | REN (0.48) | KAT6AKAT5KAT7RENEPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124582-A1 | RENIN INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-16 | — | — | WO | disclosed |