Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.35 |
| ▸ | REN | P00797 | 3/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746988 | 0.84 | ALDH1A1 (0.34) | RENKDM4EHPGDNPC1RAB9A | |
| SCHEMBL4748944 | 0.79 | KAT6A (0.41) | REN | |
| SCHEMBL4746196 | 0.78 | REN (0.36) | RENKDM4EHPGDNPC1GLA | |
| SCHEMBL2850288 | 0.73 | REN (0.49) | RENNPC1RAB9AGRIN2B | |
| SCHEMBL2850285 | 0.73 | REN (0.49) | RENNPC1RAB9AGRIN2B | |
| SCHEMBL5592088 | 0.67 | REN (0.41) | RENNPC1RAB9AGRIN2B | |
| SCHEMBL3880169 | 0.66 | REN (0.66) | REN | |
| SCHEMBL5592196 | 0.66 | REN (0.66) | REN | |
| SCHEMBL14403783 | 0.65 | REN (0.49) | RENCD274GRIN2B | |
| SCHEMBL3564789 | 0.64 | REN (0.47) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124582-A1 | RENIN INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-16 | — | — | WO | disclosed |