Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 5/20 | 0.55 |
| ▸ | TDP2 | O95551 | 7/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NGF | P01138 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747762 | 0.85 | TDP2 (0.49) | GSRTDP2MDM2MEN1NGF | |
| SCHEMBL4748228 | 0.85 | TDP2 (0.49) | GSRTDP2MEN1NGFNTRK1 | |
| SCHEMBL4744197 | 0.84 | TDP2 (0.48) | GSRTDP2MDM2MEN1NGF | |
| SCHEMBL4747662 | 0.83 | HRH4 (0.47) | GSRTDP2MEN1NGFNTRK1 | |
| SCHEMBL4748217 | 0.80 | TDP2 (0.62) | GSRTDP2MEN1NGFNTRK1 | |
| SCHEMBL9635797 | 0.72 | GSR (0.70) | GSRTDP2MEN1RECQLKMT2A | |
| SCHEMBL17582837 | 0.72 | GSR (0.45) | GSRMAPT | |
| SCHEMBL4746265 | 0.71 | GSR (0.61) | GSR | |
| SCHEMBL4747745 | 0.69 | MEN1 (0.48) | GSRTDP2MEN1NGFNTRK1 | |
| SCHEMBL5047468 | 0.68 | GSR (0.60) | GSRTDP2MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008114009-A1 | 10H-BENZO(G)PTERDINE-2,4-DIONE COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | CAMBRIDGE ENTERPRISE LTD. (GB) | 2008-09-25 | — | — | WO | disclosed |
| WO-2008114009-A1 | 10H-BENZO(G)PTERDINE-2,4-DIONE COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | CAMBRIDGE ENTERPRISE LTD. (GB) | 2008-09-25 | — | — | WO | disclosed |