Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 4/20 | 0.48 |
| ▸ | GSR | P00390 | 5/20 | 0.45 |
| ▸ | MAT2A | P31153 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NGF | P01138 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747662 | 0.90 | HRH4 (0.47) | TDP2GSRMAT2AMEN1NGF | |
| SCHEMBL4747145 | 0.84 | GSR (0.55) | TDP2GSRTP53MDM2MEN1 | |
| SCHEMBL4747762 | 0.82 | TDP2 (0.49) | TDP2GSRTP53MDM2ALOX5 | |
| SCHEMBL4748228 | 0.82 | TDP2 (0.49) | TDP2GSRMEN1NGFNTRK1 | |
| SCHEMBL4748217 | 0.77 | TDP2 (0.62) | TDP2GSRTP53HPGDMEN1 | |
| SCHEMBL4748253 | 0.75 | GSR (0.48) | GSRHPGDALOX5 | |
| SCHEMBL1050380 | 0.74 | TMEM97 (0.47) | TDP2HPGDMEN1MAPTRECQL | |
| SCHEMBL9635797 | 0.69 | GSR (0.70) | TDP2GSRTP53MEN1RECQL | |
| SCHEMBL4747565 | 0.69 | GSR (0.48) | GSRMAT2AHPGD | |
| SCHEMBL4747745 | 0.66 | MEN1 (0.48) | TDP2GSRTP53HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008114009-A1 | 10H-BENZO(G)PTERDINE-2,4-DIONE COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | CAMBRIDGE ENTERPRISE LTD. (GB) | 2008-09-25 | — | — | WO | disclosed |
| WO-2008114009-A1 | 10H-BENZO(G)PTERDINE-2,4-DIONE COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | CAMBRIDGE ENTERPRISE LTD. (GB) | 2008-09-25 | — | — | WO | disclosed |