Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.51 |
| ▸ | RELA | Q04206 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2201397 | 0.71 | HPGD (0.58) | SMN1; SMN2ALOX15HSD17B10GAAKDM4E | |
| SCHEMBL429187 | 0.70 | PTPN1 (0.48) | NPC1RAB9ATP53MAPTNFKB1 | |
| SCHEMBL3559655 | 0.70 | MEN1 (0.60) | NPC1RAB9ATP53MAPTNFKB1 | |
| SCHEMBL3156267 | 0.68 | ALDH1A1 (0.50) | NPC1RAB9AMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL445135 | 0.68 | PTPN1 (0.66) | NPC1RAB9AMAPTSMN1; SMN2JAK2 | |
| SCHEMBL28482288 | 0.68 | RNASEH1 (0.68) | NPC1RAB9ATP53MAPTNFKB1 | |
| SCHEMBL31110177 | 0.68 | MAPT (1.00) | NPC1RAB9ATP53MAPTNFKB1 | |
| SCHEMBL6984067 | 0.68 | RIPK1 (0.52) | NPC1RAB9ATP53MAPTNFKB1 | |
| SCHEMBL24202631 | 0.68 | SIRT1 (0.83) | NPC1RAB9AMAPTSMN1; SMN2JAK2 | |
| N-Phenylbenzamide SCHEMBL31966 | 0.68 | SIRT1 (0.83) | NPC1RAB9AMAPTSMN1; SMN2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124524-A2 | ARYL SULFONAMIDE COMPOUNDS AS MODULATORS OF THE CCK2 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-16 | — | — | WO | claimed |
| WO-2008124524-A2 | ARYL SULFONAMIDE COMPOUNDS AS MODULATORS OF THE CCK2 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-16 | — | — | WO | disclosed |