Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGAV | P06756 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 4/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788381 | 0.95 | FAAH (0.39) | FAAHITGB3ITGAVMAOAMAOB | |
| SCHEMBL4787543 | 0.85 | ADRA2A (0.39) | ITGB3ITGAVMAOAMAOBITGA2B | |
| Acetic Acid SCHEMBL4915061 | 0.83 | ITGB3 (0.39) | ITGB3ITGAVMAOAMAOBITGA2B | |
| Formic Acid SCHEMBL4748746 | 0.82 | NISCH (0.38) | ITGB3ITGAVITGA2BWDR5SLC6A2 | |
| SCHEMBL4748639 | 0.77 | BCHE (0.46) | ITGB3ITGAVMAOAMAOBITGA2B | |
| SCHEMBL4786568 | 0.77 | HTR1B (0.49) | MAOAMAOBWDR5HTR1BSLC6A2 | |
| SCHEMBL949042 | 0.76 | KDM4E (0.52) | MAOAMAOB | |
| Iodide SCHEMBL951481 | 0.75 | KDM4E (0.51) | MAOAMAOB | |
| SCHEMBL14042569 | 0.75 | HTR1B (0.46) | ITGB3ITGAVMAOAMAOBITGA2B | |
| SCHEMBL14042330 | 0.75 | SLC6A2 (0.46) | MAOAMAOBWDR5SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123821-A1 | 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-10-16 | — | — | WO | disclosed |