Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | BAX | Q07812 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 5/20 | 0.42 |
| ▸ | BCHE | P06276 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8603380 | 0.87 | ERBB2 (0.46) | ERBB2LTA4HNR1H2BAXNPC1 | |
| SCHEMBL28876974 | 0.81 | PDGFRB (0.51) | LMNAACHEBCHEKDM4EMAPK1 | |
| SCHEMBL4744679 | 0.81 | ERBB2 (0.49) | ERBB2LTA4HLMNAACHEBCHE | |
| SCHEMBL10251583 | 0.81 | NCF1 (0.53) | ERBB2LMNAACHEBCHENPC1 | |
| SCHEMBL1486580 | 0.80 | IP6K1 (0.56) | ERBB2LMNAKDM4EMAPK1NPSR1 | |
| SCHEMBL32684711 | 0.80 | LMNA (0.69) | ERBB2LMNAKDM4EMAPK1NPSR1 | |
| SCHEMBL591852 | 0.78 | LMNA (0.62) | LMNAKDM4EMAPK1NPSR1MAPT | |
| SCHEMBL3649291 | 0.76 | L3MBTL1 (0.50) | LTA4HNR1H2BAXACHEBCHE | |
| SCHEMBL27577248 | 0.75 | MTNR1A (0.43) | LMNAKDM4EMAPK1NPSR1MAPT | |
| SCHEMBL3691354 | 0.75 | ALDH1A1 (0.48) | LMNAKDM4EMAPK1NPSR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008117079-A1 | ANTIMICROBIAL COMPOUNDS BASED UPON 4-AMINOQUINOLINE | HELPERBY THERAPEUTICS LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |
| US-20030219427-A1 | TPL-2/COT kinase and methods of use | MEDICAL RESEARCH COUNCIL (GB) | 2003-11-27 | — | — | US | disclosed |
| US-20020099169-A1 | TPL-2/COT KINASE AND METHODS OF USE | BASF AKTIENGESELLCHAFT | 2002-07-25 | — | — | US | disclosed |
| EP-1105501-A2 | TPL-2/COT KINASE AND METHODS OF USE | BASF Aktiengesellschaft (US) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000011191-A2 | TPL-2/COT KINASE AND METHODS OF USE | BASF AKTIENGESELLSCHAFT (US) | 2000-03-02 | — | — | WO | disclosed |