Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 2/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474936 | 0.91 | ADORA2A (0.42) | PPARGADORA2BPTGDR2ADORA2ASMN1; SMN2 | |
| SCHEMBL474633 | 0.84 | ALDH1A1 (0.41) | KDM4ESMN1; SMN2ALDH1A1BRD4BRPF1 | |
| SCHEMBL474397 | 0.82 | ADORA2A (0.42) | ADORA2BADORA2AKDM4EMEN1KMT2A | |
| SCHEMBL12164048 | 0.82 | TRIM24 (0.47) | PPARGADORA2BADORA2AKDM4EMEN1 | |
| SCHEMBL474296 | 0.82 | TRIM24 (0.47) | PPARGADORA2BADORA2AKDM4EMEN1 | |
| SCHEMBL474253 | 0.80 | SMN1; SMN2 (0.40) | ADORA2BADORA2AKDM4EMEN1KMT2A | |
| SCHEMBL12164042 | 0.80 | SMN1; SMN2 (0.40) | ADORA2BADORA2AKDM4EMEN1KMT2A | |
| SCHEMBL474976 | 0.78 | PTGDR2 (0.39) | PPARGPTGDR2SMN1; SMN2ALDH1A1BRPF1 | |
| SCHEMBL474975 | 0.76 | ALDH1A1 (0.35) | PTGDR2SMN1; SMN2ALDH1A1PDCD1CD274 | |
| SCHEMBL15580684 | 0.76 | TRIM24 (0.46) | PPARGADORA2BADORA2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411365-A1 | 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2012-02-01 | — | — | EP | disclosed |