Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746545 | 0.85 | ME2 (0.44) | LMNAALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL4747137 | 0.84 | L3MBTL1 (0.53) | LMNAALDH1A1HPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL4749902 | 0.83 | GPR183 (0.53) | ALDH1A1TP53L3MBTL1 | |
| SCHEMBL4749260 | 0.82 | CCNC (0.38) | LMNAALDH1A1HPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL4747050 | 0.80 | KDM4E (0.52) | LMNAALDH1A1HPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL4749877 | 0.77 | KDM4E (0.46) | LMNAALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL4749965 | 0.74 | KDM4E (0.43) | ALDH1A1HPGDKDM4EPOLBHRH4 | |
| SCHEMBL4817000 | 0.73 | ME2 (0.44) | LMNAALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL4749923 | 0.73 | KDM4E (0.44) | ALDH1A1HPGDSMN1; SMN2KDM4EPOLB | |
| SCHEMBL4809360 | 0.73 | L3MBTL1 (0.53) | LMNAALDH1A1HPGDSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123756-A1 | A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTON TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA | SK CHEMICALS CO., LTD. (KR) | 2008-10-16 | — | — | WO | claimed |