Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 5/20 | 0.41 |
| ▸ | PGR | P06401 | 4/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 6/20 | 0.36 |
| ▸ | ESRRA | P11474 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4105299 | 0.88 | AR (0.41) | ARPGRSCN9ASLC22A12ESRRA | |
| SCHEMBL4751277 | 0.86 | AR (0.40) | ARSLC22A12ESRRA | |
| SCHEMBL4752256 | 0.78 | AR (0.39) | ARPGRHPGD | |
| SCHEMBL4748718 | 0.74 | PKM (0.35) | CYP1A2CYP2C19 | |
| SCHEMBL4105432 | 0.74 | AR (0.38) | ARSLC22A12ESRRA | |
| SCHEMBL4751664 | 0.70 | RAPGEF4 (0.33) | JAK2JAK1JAK3CYP1A2CYP2C19 | |
| SCHEMBL4959670 | 0.69 | MRGPRX4 (0.39) | ARPGR | |
| SCHEMBL11753072 | 0.69 | AR (0.55) | ARPGRSLC22A12KDM4EMEN1 | |
| SCHEMBL4783229 | 0.69 | AR (0.43) | ARPGRSLC22A12 | |
| SCHEMBL4978023 | 0.69 | PGR (0.45) | ARPGRSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008135824-A1 | OXYALKYLPYRAZOLE COMPOUNDS USEFUL IN THERAPY | PFIZER LIMITED (GB) | 2008-11-13 | — | — | WO | disclosed |