Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA1 | Q09470 | 4/20 | 0.49 |
| ▸ | KCNAB1 | Q14722 | 4/20 | 0.49 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | HPN | P05981 | 1/20 | 0.42 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.42 |
| ▸ | F13A1 | P00488 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | TGM1 | P22735 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753862 | 0.86 | KCNA1 (0.65) | KCNA1KCNAB1KDM4ELMNAALDH1A1 | |
| SCHEMBL4753834 | 0.84 | KCNA1 (0.51) | KCNA1KCNAB1KDM4ELMNAALDH1A1 | |
| SCHEMBL13983989 | 0.83 | KCNA1 (0.66) | KCNA1KCNAB1KDM4ELMNAALDH1A1 | |
| SCHEMBL4753275 | 0.81 | KCNA1 (0.53) | KCNA1KCNAB1KDM4ELMNAALDH1A1 | |
| SCHEMBL13983859 | 0.79 | KCNA1 (0.52) | KCNA1KCNAB1KDM4ELMNAALDH1A1 | |
| SCHEMBL4751184 | 0.78 | KDM4E (0.52) | KCNA1KCNAB1KDM4ELMNACA1 | |
| Ammonia Solution, Strong SCHEMBL4811566 | 0.77 | KDM4E (0.51) | KCNA1KCNAB1KDM4ELMNACA1 | |
| SCHEMBL4753300 | 0.73 | ALDH1A1 (0.45) | KDM4ELMNAALDH1A1HPGD | |
| SCHEMBL28565628 | 0.73 | ALDH1A1 (0.60) | LMNACA1CA2TMEM97SIGMAR1 | |
| SCHEMBL23854680 | 0.73 | DHFR (0.60) | DHFRTMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008149163-A2 | POTASSIUM ION CHANNEL MODULATORS AND USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2008-12-11 | — | — | WO | claimed |
| WO-2008149163-A2 | POTASSIUM ION CHANNEL MODULATORS AND USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2008-12-11 | — | — | WO | disclosed |
| WO-2008149163-A2 | POTASSIUM ION CHANNEL MODULATORS AND USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2008-12-11 | — | — | WO | disclosed |