Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27801284 | 0.87 | SIGMAR1 (0.49) | SIGMAR1BCHELMNAMAOB | |
| SCHEMBL691442 | 0.86 | BCHE (0.46) | SIGMAR1BCHEMAOB | |
| SCHEMBL27765696 | 0.81 | SIGMAR1 (0.56) | SIGMAR1LMNAPOLB | |
| SCHEMBL4812815 | 0.79 | AGTR2 (0.43) | BCHE | |
| SCHEMBL2628898 | 0.79 | AGTR2 (0.52) | SIGMAR1LMNA | |
| SCHEMBL3206960 | 0.78 | BCHE (0.60) | BCHEMAOB | |
| SCHEMBL9685669 | 0.78 | BCHE (0.60) | BCHEMAOB | |
| SCHEMBL2893650 | 0.78 | BCHE (0.60) | BCHEMAOB | |
| SCHEMBL9818951 | 0.77 | BCHE (0.44) | BCHEPOLB | |
| SCHEMBL18498897 | 0.77 | S1PR5 (0.53) | BCHEMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008139941-A1 | SUBSTITUTED IMIDAZOLE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-20 | — | — | WO | disclosed |
| EP-1984355-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | Takeda Pharmaceutical Company Limited (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |