Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 6/20 | 0.46 |
| ▸ | PKLR | P30613 | 1/20 | 0.46 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.41 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4752457 | 0.83 | PKM (0.41) | PKMPKLRCYP26A1CYP26B1THRB | |
| SCHEMBL4754001 | 0.81 | PKM (0.41) | PKMPKLRCYP26A1CYP26B1MAPT | |
| SCHEMBL4788883 | 0.78 | TSHR (0.39) | PKMCYP26A1CYP26B1MAPTALDH1A1 | |
| SCHEMBL4787216 | 0.74 | AKT1 (0.38) | MAPTALDH1A1 | |
| SCHEMBL4868478 | 0.70 | LMNA (0.42) | PKMMAPTALDH1A1NPSR1 | |
| SCHEMBL4750485 | 0.68 | HTR2A (0.51) | PKMALDH1A1NPSR1 | |
| SCHEMBL10361762 | 0.67 | MAPT (0.65) | PKMPKLRHSD17B3HSD17B2MAPT | |
| SCHEMBL31589145 | 0.67 | CDK1 (0.60) | PKMPKLRHSD17B3HSD17B2MAPT | |
| SCHEMBL7571133 | 0.65 | MAPT (0.63) | MAPTTDP1CDK1CCNB1CCNA2 | |
| SCHEMBL7563643 | 0.65 | CES1 (0.72) | HSD17B3HSD17B2MAPTTDP1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008146064-A1 | NEW BENZOFURAN DERIVATIVES AS SELECTIVE 5HT7 RECEPTOR INHIBITORS AND PROCESS FOR THEIR PREPARATION | EGIS GYÓGYSZERGYÁR (HU) | 2008-12-04 | — | — | WO | disclosed |