Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | UBE2N | P61088 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4756695 | 0.81 | HSD11B1 (0.39) | PDE9AKDM4EALDH1A1HPGDUSP30 | |
| SCHEMBL4753279 | 0.72 | FASN (0.32) | PDE9AKDM4EALDH1A1HPGDUSP30 | |
| SCHEMBL4755648 | 0.71 | PIK3CA (0.35) | PDE9AKDM1A | |
| SCHEMBL4753259 | 0.68 | PIK3CA (0.35) | PDE9A | |
| SCHEMBL4755201 | 0.67 | HSD11B1 (0.38) | KDM4EALDH1A1HPGDUSP30PSD | |
| SCHEMBL4753738 | 0.66 | JAK2 (0.35) | PDE9A | |
| SCHEMBL4755140 | 0.65 | HSD11B1 (0.38) | USP30PSDHSD11B1KIT | |
| SCHEMBL13746898 | 0.65 | HSD11B1 (0.39) | PDE9AKDM4EALDH1A1HPGDKDM1A | |
| SCHEMBL13747135 | 0.64 | HSD11B1 (0.35) | PDE9AKDM4EALDH1A1HPGDHSD11B1 | |
| SCHEMBL3074271 | 0.59 | CHEK1 (0.59) | SLC11A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |