Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | VHL | P40337 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.30 |
| ▸ | KRAS | P01116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753259 | 0.82 | PIK3CA (0.35) | PIK3CAKDM5BVHLDGAT1PDE4A | |
| SCHEMBL4753738 | 0.77 | JAK2 (0.35) | PIK3CAKDM5BVHLDGAT1PDE4A | |
| SCHEMBL4753279 | 0.72 | FASN (0.32) | PDE9A | |
| SCHEMBL4753233 | 0.71 | PDE9A (0.37) | PDE9AKDM1A | |
| SCHEMBL13745966 | 0.68 | TYMS (0.32) | PIK3CA | |
| SCHEMBL13985419 | 0.68 | PDE4B (0.34) | PIK3CASYKKDM1A | |
| SCHEMBL4756614 | 0.67 | KDM4E (0.33) | — | |
| SCHEMBL13746012 | 0.67 | PIK3CA (0.36) | PIK3CAKDM5BVHLDGAT1PDE4A | |
| SCHEMBL4756695 | 0.65 | HSD11B1 (0.39) | PDE9AKDM1A | |
| SCHEMBL13660413 | 0.62 | DPP4 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | claimed |
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |