Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.32 |
| ▸ | LPL | P06858 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.31 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.31 |
| ▸ | USP14 | P54578 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RHOA | P61586 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755067 | 0.88 | AVPR1A (0.37) | TBK1GRM5AVPR1APDE4BKDM4E | |
| SCHEMBL13985224 | 0.84 | TBK1 (0.33) | TBK1AKR1C3CHRM4LPLLIPG | |
| SCHEMBL4755767 | 0.78 | CHRNB2 (0.34) | PIK3CAAVPR1ACHRNB2CHRNA4USP14 | |
| SCHEMBL4755765 | 0.78 | CHRNB2 (0.34) | PIK3CAAVPR1ACHRNB2CHRNA4USP14 | |
| SCHEMBL4755763 | 0.75 | PIK3CA (0.36) | CHRM4PIK3CAAVPR1ACHRNB2CHRNA4 | |
| SCHEMBL4755760 | 0.75 | PIK3CA (0.36) | CHRM4PIK3CAAVPR1ACHRNB2CHRNA4 | |
| SCHEMBL3174423 | 0.73 | PDE4B (0.36) | PDE4BPDE4DCHRNB2CHRNA4USP14 | |
| SCHEMBL3174425 | 0.73 | PDE4B (0.36) | PDE4BPDE4DCHRNB2CHRNA4USP14 | |
| SCHEMBL13985414 | 0.73 | DGAT1 (0.33) | — | |
| SCHEMBL3169414 | 0.71 | YTHDC1 (0.35) | PIK3CAPDE4BPDE4DCHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |