Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4752450 | 0.88 | LMNA (0.36) | ALDH1A1KDM4EMEN1KMT2AMCOLN3 | |
| SCHEMBL4750506 | 0.83 | AKT1 (0.36) | ALDH1A1KDM4EMEN1KMT2AMCOLN3 | |
| SCHEMBL4754001 | 0.80 | PKM (0.41) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4752959 | 0.75 | HTR2A (0.47) | ALDH1A1NPC1FFAR4HTR1ALMNA | |
| SCHEMBL4750508 | 0.74 | FFAR4 (0.36) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL4751070 | 0.72 | ALDH1A1 (0.41) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL4789318 | 0.70 | AKT1 (0.34) | — | |
| SCHEMBL7963661 | 0.68 | NPC1 (0.55) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL4751068 | 0.68 | ALDH1A1 (0.41) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4750498 | 0.65 | FFAR4 (0.36) | MAPTALDH1A1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948660-A1 | TETRACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2008-07-30 | — | — | EP | claimed |
| WO-2007054741-A1 | TETRACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-05-18 | — | — | WO | claimed |
| WO-2008146064-A1 | NEW BENZOFURAN DERIVATIVES AS SELECTIVE 5HT7 RECEPTOR INHIBITORS AND PROCESS FOR THEIR PREPARATION | EGIS GYÓGYSZERGYÁR (HU) | 2008-12-04 | — | — | WO | disclosed |