Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SMO | Q99835 | 2/20 | 0.46 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751033 | 0.76 | SMO (0.59) | SMOKDM4EHTTLMNAALDH1A1 | |
| SCHEMBL4753305 | 0.70 | NPC1 (0.53) | SMOHTTALDH1A1MAPTMAPK1 | |
| SCHEMBL5338313 | 0.69 | SMO (0.59) | SMOKDM4ESMN1; SMN2MAPK1P2RX7 | |
| SCHEMBL13020231 | 0.67 | OPRM1 (0.47) | SMOMAPK1P2RX7NPC1RAB9A | |
| SCHEMBL1195590 | 0.65 | NPC1 (0.73) | P2RX7NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL8511047 | 0.65 | PDE4B (0.62) | L3MBTL1HTTALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1194352 | 0.64 | P2RX7 (0.70) | P2RX7 | |
| SCHEMBL11722513 | 0.64 | CA12 (0.70) | HTTLMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL28709587 | 0.64 | SIGMAR1 (0.56) | BLML3MBTL1HTTLMNAALDH1A1 | |
| SCHEMBL466792 | 0.63 | ALDH1A1 (0.54) | KDM4EHTTLMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |