Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 6/20 | 0.34 |
| ▸ | FLT3 | P36888 | 6/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 5/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.32 |
| ▸ | PARP6 | Q2NL67 | 2/20 | 0.32 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.32 |
| ▸ | TNKS | O95271 | 2/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755127 | 0.83 | PDE4B (0.35) | LRRK2KCNH2 | |
| SCHEMBL4756663 | 0.79 | RORC (0.35) | KCNH2 | |
| SCHEMBL4755763 | 0.72 | PIK3CA (0.36) | LRRK2 | |
| SCHEMBL4755760 | 0.72 | PIK3CA (0.36) | LRRK2 | |
| SCHEMBL4755548 | 0.70 | PDE4B (0.35) | LRRK2 | |
| SCHEMBL4755555 | 0.70 | PDE4B (0.35) | LRRK2 | |
| SCHEMBL13985224 | 0.68 | TBK1 (0.33) | — | |
| SCHEMBL4755228 | 0.68 | DRD1 (0.40) | KMT2AKDM4EMAPTKCNH2 | |
| SCHEMBL4755225 | 0.68 | DRD1 (0.40) | KMT2AKDM4EMAPTKCNH2 | |
| SCHEMBL4756551 | 0.68 | DRD1 (0.40) | KMT2AKDM4EMAPTKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | claimed |