Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
| ▸ | USP14 | P54578 | 6/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.30 |
| ▸ | DRD4 | P21917 | 2/20 | 0.30 |
| ▸ | DRD3 | P35462 | 2/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755127 | 0.87 | PDE4B (0.35) | USP14PDE4BDRD2DRD3KCNH2 | |
| SCHEMBL13985527 | 0.81 | HSD11B1 (0.36) | RORCHSD11B1CXCR3AVPR1AUSP14 | |
| SCHEMBL13985228 | 0.79 | CRHR1 (0.35) | RORCHSD11B1AVPR1AUSP14CRHR1 | |
| SCHEMBL4756580 | 0.79 | USP14 (0.36) | HSD11B1AVPR1AUSP14CRHR1 | |
| SCHEMBL4756534 | 0.79 | KIT (0.34) | KCNH2 | |
| SCHEMBL13985417 | 0.76 | HSD11B1 (0.37) | HSD11B1AVPR1AUSP14CRHR1DRD2 | |
| SCHEMBL13985520 | 0.76 | USP14 (0.38) | HSD11B1AVPR1AUSP14DRD2DRD4 | |
| SCHEMBL4755555 | 0.73 | PDE4B (0.35) | USP14PDE4B | |
| SCHEMBL4755548 | 0.73 | PDE4B (0.35) | USP14PDE4B | |
| SCHEMBL4755228 | 0.73 | DRD1 (0.40) | RORCAVPR1ACRHR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | claimed |